Robert J. Cottone,Steven Rowland,Michael John Bradley Kutryk,Horace R. Davis
申请号：
US15684453
公开号：
US20180036118A1
申请日:
2017.08.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
