One or more devices, systems, methods and storage mediums for performing ablation planning and/or ablation performance are provided. Examples of applications for such devices, systems, methods and storage mediums include imaging, evaluating and diagnosing biological objects, such as, but not limited to, lesions and tumors, and such devices, systems, methods and storage mediums may be used for radiotherapy applications (e.g., to determine whether to place seed(s) for radiotherapy). Preferably, a medial axis or a center line for a predetermined biological object (e.g., a lesion or tumor) is determined/found, one or more target points are picked along the medial axis or center line, and the ablation or radiotherapy zones are defined and optimized. Security checks may be performed in one or more embodiments to ensure proper use of the equipment and patient information.