A protective brace has a base strap, an annular pressure strap and a fastening member. The base strap includes a first end and a second end. The pressure strap is secured to the first end of the base strap and is movable through the second end of the base strap. The fastening member is movably mounted on the pressure strap and includes a fastening surface. The fastening surface faces the first end of the base strap and is fastened detachably to the pressure strap or the base strap. For a user to wear the protective brace, the base strap is first wrapped around a body part and the fastening member is then operated to make the pressure strap wrapped around the base strap and is fastened to the pressure strap or the base strap. Therefore, the protective brace can be easily worn on the users body.