A surgical instrument system (1) for treatment of an anatomical structure (3, 5) comprises an instrument (8) and/or a patient specific instrument (2, 4) for performing the treatment on the anatomical structure. The instrument (8) and/or the patient specific instrument (2, 4) comprises an integrated measurement system (20, 40, 80) for tracking the instrument (8) and/or the patient specific instrument (2, 4) relative to the anatomical structure (3, 5), whereby the integrated measurement system comprises a tracking system (6, 10), which comprises a shadow imaging tracking system.
