Delivering functional nucleic acids to mammalian cells via bacterially derived intact minicells

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专利权人:

Engeneic Molecular Delivery Pty Ltd

发明人:

Brahmbhatt, Himanshu,MacDiarmid, Jennifer

申请号：

AU2010212520

公开号：

AU2010212520B2

申请日:

2010.08.24

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2010212520B220130131.pdf#####Abstract Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.

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