LEE, CHIA HUNG,李佳洪,李佳洪,LO, LEU WEI,罗履维,羅履維,MOU, CHUNG YUAN,牟中原,牟中原,YANG, CHUNG SHI,杨重熙,楊重熙
申请号：
TW097140731
公开号：
TWI394583B
申请日:
2008.10.23
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention relates to a drug release system comprising a drug molecule and a quaternary ammonium functionalized mesoporous silica nanoparticle (MSN) wherein said drug molecule is loaded and retain in the MSN at a lower pH and released at a higher pH. The drug release system of the invention is pH responsive and thus organ-specific.本發明係關於一種藥物釋放系統,其包含藥物分子以及四級銨鹽官能化的中孔洞奈米矽球(mesoporous silica nanoparticle,MSN),在較低pH下,該藥物分子被負載且維持在該MSN中,而在較高pH下,該藥物分子被釋出。本發明之藥物釋放系統為pH反應型且因此具靶向專一性。
