SMID PIETER,LANGE JOSEPHUS H M,NUNEZ-GARCIA SARA,MLINARIC MICHAEL,KOEHLER KONRAD F,WEGENER ELMAR
申请号：
ZA201104041
公开号：
ZA201104041B
申请日:
2011.05.31
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
This invention concerns spiro azepane-ox-azolidinones as voltage gated Kv1.3 potassium channel blockers, pharmaceutical compositions containing these compounds, methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in the treatment of diabetes, psoriasis, obesity, transplant rejection and inflammatory neuropathies, including T-cell mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. The compounds have formula (1): wherein R1, R2, (R3)n, and (R4)m have the meanings given in the specification.
