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2,5-DI-HYDRO-3H-PIRAZOLE [4,3-C] PYRIDAZIN-3-ONA DERIVATIVES SUBSTITUTED, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
- 专利权人:
- SANOFI-AVENTIS
- 发明人:
- CHRISTIAN CONGY,VICTOR DOS SANTOS,MURIELLE RINALDI-CARMONA,ARNAUD ROUQUETTE,DIDIER VAN BROECK
- 申请号：
- BRPI0719291
- 公开号：
- BRPI0719291A2
- 申请日:
- 2007.11.19
- 申请国别(地区):
- BR
- 年份:
- 2014
- 代理人:
- 摘要：
- Pyrazolopyridazinone compounds (I), and their addition salts, hydrates and solvates are new. Pyrazolopyridazinone compounds of formula (I), and their addition salts, hydrates and solvates are new. R 11-12C alkyl (optionally substituted by F), non-aromatic 3-12C carbocyclic (optionally substituted by 1-4C alkyl, 1-4C alkoxy, F, OH, CF 3, OCF 3 or 1-4C alkylthio), phenyl (optionally substituted by halo, OH, Alk, -OAlk, methylenedioxy, -CH 2-NHAlk, -CH 2N(Alk) 2, CN, NO 2, S(O) nAlk, OS(O) nAlk, 1-4C alkylcarbonyl, 1-4C alkoxycarbonyl or phenyl, phenoxy, pyrrolyl, imidazolyl, pyridyl, pyrazolyl, oxazolyl, thiazolyl, triazolyl or thiadiazolyl, optionally substituted by 1-4C alkyl), benzyl (optionally substituted on phenyl by halo, Alk, OH, OAlk, methylenedioxy, S(O) nAlk or -OS(O) nAlk), phenethyl (optionally substituted on phenyl by halo, 1-4C alkyl, 1-4C alkoxy, CF 3 or OCF 3), benzhydryl, benzhydrylmethyl, heterocyclic aromatic comprising pyrrolyl, imidazolyl, furyl, thienyl, pyrazolyl, oxazolyl, pyridyl, indolyl, benzothienyl or thieno[3,2-b]thienyl, optionally substituted by halo, Alk, OAlk, CN, NO 2 or -S(O) nAlk； R 2phenyl (optionally substituted by halo, OH, Alk, OAlk, -S(O) nAlk or -OS(O) nAlk)； R 3phenyl (optionally substituted by halo, OH, Alk, OAlk, -S(O) nAlk or OS(O) nAlk)； R 4H, 1-4C alkyl, 1-4C alkoxy or OH； n : 0-2； and Alk : 1-4C alkyl (optionally substituted by F). Independent claims are included for: (1) the preparation of (I)； and (2) pyrazolopyridazinone compound of formula (II). ACTIVITY : Neuroleptic； Nootropic； Tranquilizer； Neuroprotective； Metabolic； Anorectic； Antidiabetic； Analgesic； Antianginal； Antilipemic； Gastrointestinal-Gen； Antiemetic； Antidiarrheic； Antiulcer； Hepatotropic； Immunomodulator； Antiarthritic； Antirheumatic； Antiinflammatory； Antiparkinsonian； Antismoking； Antidepressant； Hypnotic； Antialcoholic； Antimigraine； Anticonvulsant； Muscular-Gen.； Inotropic； Vasotropic； Cerebroprotective； Antiaddictive； Eating-Disorders-Gen； Car
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
