The present invention relates to the field of vaccines directed against viruses of the HIV family. More particularly , it relates to an immunogenic compound comprising a peptide of the following formula (I) NH 2 -[Nt] y - P -W- N- X- S- X 2 - S- N- X 3 - X 4 -X -X 6 -X 7 -I- W -[Ct] z- COOH (I) which is covalently linked to a carrier protein consisting of a CRM197 protein. It also concerns a composition containing this immunogenic compound and the uses of these immunogenic compounds and compositions for preventing and/or treating a condition caused by the infection of an individual with a HIV virus.