NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY;OSAKA UNIVERSITY;MITSUBISHI TANABE PHARMA CORPORATION
发明人:
HASHIMOTO, Motonori,YAMASHITA, Toshihide
申请号：
PE0023202017
公开号：
PE02512018A1
申请日:
2016.04.27
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Referring to a Binding Protein Repellent (isolated Molecule RGMa Guide)No Inhibits the binding between the Molecule Guide Repellent (RGMa) and neogenina but neutralizes the growth Inhibitory activity of neutritico RGMa,Preferably providing Antibody anti RGMa has complementarity determining regions that have amino acid sequences of SEQ ID Nos: 30 - 35 or SEQ ID no: 36 - 40 in the listSequences, and SFG.Useful for preventing, treating or Preventing Relapse of Neurological or immunological diseases, such as: Brachial Plexus Injury, Cerebral Palsy, multiple sclerosis,Neuromyelitis optica, among others.It also relates to a Pharmaceutical composition, a Nucleic Acid Molecule, a recombinant vector, host cell and a method for producing Protein Binding to GMR -.Referido a una proteina de union a Molecula Guia Repelente A (RGMa aislada), que no inhibe la union entre la Molecula Guia Repelente a (RGMa) y neogenina pero neutraliza la actividad inhibidora del crecimiento neutritico de RGMa, preferiblemente proporcionando un anticuerpo anti-RGMa que tiene regiones determinantes de complementariedad que tienen secuencias de aminoacidos de SEQ ID NOS: 30-35 o SEQ ID NO: 36-40 en el listado de secuencias, y SFG. Utiles para prevenir, tratar o prevenir la recaida de enfermedades neurologicas o inmunologicas, tales como: lesion del plexo braquial, paralisis cerebral, esclerosis multiple, neuromielitis optica entre otros. Tambien se refiere a una composicion farmaceutica, una molecula de acido nucleico, un vector recombinante, una celula hospedera y un metodo para producir la proteina de union a RGM-a.
