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COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL ARTERIAL DISEASE
专利权人:
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
发明人:
ANNEX, BRIAN, H.,FARBER, CHARLES, R.,HAZARIKA, SUROVI
申请号:
EP13829411
公开号:
EP2885008A4
申请日:
2013.08.15
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present application discloses roles for miR-93 in treating hypoxia and ischemia. Endothelial cells (HUVEC) and myocytes (C2C12) expressed miR-93 and up-regulated miR-93 in response to hypoxia and serum starvation. Over-expression of miR-93 in HUVECs promoted cell proliferation, prevented hypoxia-induced apoptosis, and enhanced endothelial cell tube formation. miR-93 knockdown in HUVECs resulted in increased hypoxia-induced apoptosis and decreased tube formation. Over-expression or knockdown of miR-93 in myocytes resulted in reduced or increased hypoxia-induced apoptosis, respectively. Down-regulation of miR-93 in C57BL/6 mice with antagomiR resulted in attenuated perfusion recovery (% non-ischemic leg at day-21: Scramble 85.22.9 vs. AntagomiR-93 67.96). Over-expression of miR-93 in BALB/C mice improved perfusion recovery (% non-ischemic leg at day 21: PremiR-93 757.5 vs. Scramble 59.62.5). The present invention encompasses the use of miR-93 and regulation of miR-93 to treat and prevent hypoxia, ischemia, and other injuries, diseases, disorders, and conditions associated with ischemia.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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