An example method of treating a subject having a tumor is described herein. The method can include determining a radiosensitivity index of the tumor deriving a subject specific variable based on the radiosensitivity index and obtaining a genomic adjusted radiation dose effect value for the tumor. The radiosensitivity index can be assigned from expression levels of signature genes of a cell of the tumor. Additionally the genomic adjusted radiation dose effect value can be predictive of tumor recurrence in the subject after treatment. The method can also include determining a radiation dose based on the subject specific variable and the genomic adjusted radiation dose effect value.
