ХОТОСИ Ясумити (US),ХОЛЛАНД Саша (US),ПАЙЯН Дональд Дж. (US)
申请号：
RU2011132118/15
公开号：
RU2011132118A
申请日:
2010.01.15
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method for preventing, treating or managing metastatic cancer in a patient in need thereof, wherein a therapeutically or prophylactically effective amount of an Axl inhibitor and a therapeutically or prophylactically effective amount of one or more chemotherapeutic agents are administered to the patient. The method according to claim 1, where the Axl inhibitor is a compound of formula (I): where: R, R and R are independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, aralkyl, —C (O) R, - C (O) N (R) R and —C (= NR) N (R) R； R and R are, independently of each other, a polycyclic heteroaryl containing more than 14 ring atoms, optionally substituted with one or more substituents selected from the group consisting of oxo, thioxo, cyano, nitro, halo, haloalkyl, alkyl, possibly substituted cycloalkyl, possibly substituted cycloalkylalkyl, optionally substituted aryl, possibly substituted aralkyl, possibly substituted heteroaryl, possibly substituted heterocyclyl, -R-OR, -ROR-OR, -ROROR-OR, -ROR-CN, -RORC (O) OR, -RORC (O) N (R ) R, -RORS (O) R (where p represents 0, 1 or 2), -RORN (R) R, -RORC (NR) N (R) H, -R-OC (O) -R, - RN (R) R, -RC (O) R, -RC (O) OR, -RC (O) N (R) R, -RN (R) C (O) OR, -RN (R) C (O ) R, -RN (R) S (O) R (where t represents 1 or 2), -RS (O) OR (where t represents 1 or 2), -RS (O) R (where p represents 0, 1 or 2) and -RS (O) N (R) R (where t is 1 or 2)； or R is a polycyclic heteroaryl containing more than 14 ring atoms as described above, and R is selected from the groups Consisting of aryl and heteroaryl, wherein aryl and heteroaryl are independently optionally substituted with one or more than one substituent selected from the group consisting of alkyl, alkenyl, alkynyl, halo, g1. Способ предотвращения, лечения или управления метастатическим раком у пациента, нуждающегося в этом, согласно которому вводят пациенту терапевтически или профилактически эффективное количество ингибитора Axl и терапевтически или профилактически
