A method of using a medicine injection device including a syringe filled with a medicine； a needle tube having a needle tip for puncturing the skin； a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when the living body is punctured with the needle tube； and an absorption part that is disposed in the skin contact portion of the needle hub. The method includes removing air from the medicine injection device prior to injection of the medicine, whereby medicine spilled from the needle tip is caught in the skin contact portion； the absorption part absorbing the spilled medicine staying in the skin contact portion； positioning the skin contact portion adjacent the skin； puncturing the skin with the needle tip； and injecting medicine from the needle tip into the skin.
