Formula I [Formula 1] In the formula, m and 2, n R 1, R are as described in the specification] compound represented by the manufacturing method thereof, pharmaceutical compositions containing them and their use.式I【化1】[式中、R1、R2、nおよびmは明細書中に記載の通りである]で示される化合物、その製造方法、それらの使用およびそれらを含む医薬組成物。