A left atrial appendage closure device (200) comprising: a sealing member (220)； a fixing member (210) located on one side of the sealing member (220)； and between the sealing member (220) and the fixing member (210). A connecting member (230) to be connected. The radial deformation capability of the sealing member (220) is greater than the radial deformation capability of the fixing member (210) and / or the axial deformation capability of the sealing member (220) is axial direction of the fixing member (210). Greater than deformability. In the left atrial appendage closure device (200), if the sealing member (220) is installed such that the radial or axial deformation capability of the sealing member (220) is larger than the radial or axial deformation capability of the fixing member (210), the fixing member ( After placing 210) on the left atrial appendage (10), the closure effect can be enhanced to prevent the sealing member (220) from being optimally attached to the opening of the left atrial appendage. At the same time, the deformability of the sealing member (220) is great, reducing the risk of wear of the sealing member (220) or breaking through the left atrial appendage opening. Given the assurance of the two advantages described above, the fixation member (210) better secures the closure device to the left atrial appendage (10) to prevent the closure device (200) from detaching from the left atrial appendage.左心耳閉鎖装置（２００）であって、密閉部材（２２０）と、密閉部材（２２０）の片側に位置する固定部材（２１０）と、該密閉部材（２２０）と固定部材（２１０）の間を連結する連結部材（２３０）と、を含む。該密閉部材（２２０）の径方向変形能力は該固定部材（２１０）の径方向変形能力より大きく、及び／または該密閉部材（２２０）の軸方向変形能力は該固定部材（２１０）の軸方向変形能力より大きい。該左心耳閉鎖装置（２００）において、密閉部材（２２０）の径方向または軸方向変形能力が、固定部材（２１０）の径方向または軸方向変形能力より大きくなるように設置すれば、固定部材（２１０）を左心耳（１０）に配置した後、密閉部材（２２０）が左心耳の開口部に最適に密着できないことを防ぐため、閉鎖効果を増強することができる。同時に、密閉部材（２２０）の変形能力が大きいため、密閉部材（２２０）の摩損または左心耳の開口部を突き破るリスクを低減させる。前述の２つの利点を保証する前提で、固定部材（２１０は）閉鎖装置を更によく左心耳（１０）に固定させて、閉鎖装置（２００）が左心耳から離脱することを回避する。
