The invention relates to the use of extracts of cannabis plants for treating neurological degeneration .such as alzheimers, huntingdons and parkinsons diseases, dementia, multiple sclerosis, Downs syndrome, prion disease, palsy, spinal cord injury or alcohol induced neurotoxicity. Preferably the extract contains a cannabinoid:non-cannabinoid fraction in a ratio of between 60:40 90:10. The cannabinoid fraction may contain tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabidivarin (THCV), cannabigerol (CBG), cannabichromeme (CBC) tetrahydrocannabinolic acid (THCA), cannabidivarin (CBDV) and cannadidiolic acid (CBDA).