Nemunaitis, John J.,Senzer, Neil,Maples, Phillip B.,Rao, Donald
申请号：
AU2016208280
公开号：
AU2016208280A1
申请日:
2016.07.26
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016208280A120160811.pdf#####ABSTRACT The present invention includes compositions and methods for cancer treatment. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-3 through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.WO 2011/079077 PCT/US2010/061344 2/17 GMCSF Expression In Pre & Post FANG Plasmid Transfected Autologous Tumor Cells (Day 4) 2000 2000 "-"F A NG -00 1 ~FANG-002 1500 FANG-005 e. F ANG-06 1000 - FANG-007 FANG-00 500 ----F A N G -0 103 j1g. ic TGF.1 Expression by FANG-004 (NSCLC) pre and post transfection/post irradiated cells 4000 3500 3000 2500 -2000 1500 1000 500 0 r DayO Dayl Day2 Day3 Day4 Day7 Day10 Dayl4 jiN. 20A
