The present invention relates to bacterial-derived vesicles of the genus Excigubacterium and uses thereof, and the present inventors compared to normal people with stomach cancer, colon cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer, myocardial infarction, stroke, diabetes, And in the clinical sample of Parkinson''s disease patients, the vesicles were significantly reduced, and when the vesicles isolated from the strain were administered, it was experimentally confirmed that the inflammatory mediator secretion by pathogenic vesicles such as E. coli-derived vesicles was significantly suppressed. The bacterial-derived vesicles of the genus Excigubacterium according to the present invention include gastric cancer, colon cancer, pancreatic cancer, bile duct cancer, breast cancer, ovarian cancer, bladder cancer, prostate cancer, myocardial infarction, stroke, diabetes, or Parkinson''s disease diagnosis method, and the disease It may be usefully used for the purpose of developing a composition for prevention, improvement or treatment.본 발명은 엑시구오박테리움 속 세균 유래 소포 및 이의 용도에 관한 것으로, 본 발명자들은 정상인에 비하여 위암, 대장암, 췌장암, 담관암, 유방암, 난소암, 방광암, 전립선암, 심근경색, 뇌졸중, 당뇨병, 및 파킨슨병 환자의 임상샘플에서 상기 소포가 유의하게 감소되어 있었고, 상기 균주에서 분리한 소포를 투여하였을 때 대장균 유래 소포와 같은 병원성 소포에 의한 염증매개체 분비를 현저히 억제함을 실험적으로 확인하였는바, 본 발명에 따른 엑시구오박테리움 속 세균 유래 소포는 위암, 대장암, 췌장암, 담관암, 유방암, 난소암, 방광암, 전립선암, 심근경색, 뇌졸중, 당뇨병, 또는 파킨슨병의 진단방법, 및 상기 질환에 대한 예방, 개선 또는 치료용 조성물을 개발하기 위한 목적으로 유용하게 이용될 수 있을 것이다.
