Katsuyuki Murase,Syed F. A. Hossainy,Irina Astafieva,Li Zhao,Hong Ma
申请号：
US11946026
公开号：
US08101565B2
申请日:
2007.11.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
