KIM, KAB SIGKR,김갑식,PARK, JOO WONKR,박주원,LEE, EUN YONGKR,이은용
申请号：
KR1020160034450
公开号：
KR1020170110285A
申请日:
2016.03.23
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to an erlotinib nanoparticle, a manufacturing method thereof, and a pharmaceutical composition containing the erlotinib nanoparticle, capable of making a patient more conveniently take a medicine by reducing a deviation between moments before and after a meal with an increase in the bioavailability of the medicine. The erlotinib nanoparticle is a solid dispersing body, made by dispersing an erlotinib free base in a diluting agent, and has D90 which is not more than 1000 nm. The diluting agent is selected from among a biocompatible polymer, a surfactant, saccharide, and a combination of the ingredients. The saccharide is selected from among a monosaccharide compound, a disaccharide compound, a polysaccharide compound, sugar-alcohol, and a combination of the ingredients.COPYRIGHT KIPO 2017본 발명은 약물의 생체이용률을 증가시켜 식전식후 편차를 줄임으로써 환자의 복용편의성을 개선할 수 있는 엘로티닙 나노입자 및 그 제조방법, 및 엘로티닙 나노입자를 함유하는 약학 조성물에 관한 것이다.
