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Microneedle array
专利权人:
FUJIFILM Corporation
发明人:
Shimada, Toshio
申请号:
AU2017251040
公开号:
AU2017251040A1
申请日:
2017.04.12
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The present invention addresses the problem of providing a microneedle array for which liposome aggregation can be suppressed when mixing a water-soluble polymer with liposomes and in which medicine can be localized at a tip of a needle portion during the production of the microneedle array. According to the present invention, the microneedle array includes a sheet portion, and a plurality of needle portions on an upper surface of the sheet portion, the needle portions including a water-soluble polymer, medicine, liposome, and salt. The liposome has a zeta potential of -10 mV or less, the zeta potential being the zeta potential of a liquid in which the liposome is diluted to 0.1 mg/mL with 10 mmol/L of an aqueous phosphoric acid solution having a pH of 7. The salt content of the portion of each needle portion that contains the liposome is 2.5 mmol/g or less.
来源网站:
中国工程科技知识中心
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