A wearable system detects an opioid overdose and transmits a distress message with the wearer's GPS coordinates to one or more emergency response contacts. Concurrently, the system wirelessly signals a relay which energizes a solenoid injector, causing a prescribed dosage of an opioid antidote to be injected by a syringe into the wearer's body through a subcutaneous cannula, preferably located on the wearer's wrist. Detection of an opioid overdose is based on a symptomatic depressed heart rate, which is measured by a monitor worn on the chest.