Macdonald, Gregor James,Tresadern, Gary John,Trabanco-Suarez, Andres Avelino,Pastor-Fernandez, Joaquin
申请号：
AU2010332819
公开号：
AU2010332819B2
申请日:
2010.12.16
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.
