Rajiv R. Ratan,Ishraq Alim, I,Saravanan Karuppagounder
申请号：
US15969742
公开号：
US20180327456A1
申请日:
2018.05.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention relates to methods of administering compounds containing selenium, selenocysteine, or a selenocysteine peptide to treat, for example, conditions associated with selenium deficiency, or ferroptoptic, parthanototic, and endoplasmic reticulum stress, and/or cancer. The methods of treatment may activate or inhibit (via TFAP2C and Sp1 proteins) the adaptive homeostatic response of the selenome. The compounds may contain a targeting sequence that causes them to be delivered to specific organs and/or tissues. The compounds may be administered, for example, orally, intranasally, intravenously, or by a minimally invasive catheter or BrainPath.
