In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.在一些實施方式中,具有易碎連接件的藥用小瓶聯結組包括:多個藥用小瓶,其排列成藥用小瓶組,所述多個藥用小瓶中的每一個被定型並定位設置以最小化所述藥用小瓶組的總體積,每一個藥用小瓶包括至少一個外側面,所述至少一個外側面具有被構造成與相鄰藥用小瓶的相應外側面和表面可撤銷地匹配的表面;和多個易碎連接件,其中至少一個易碎連接件固定至所述藥用小瓶組內所述多個藥用小瓶中的至少兩個的所述表面,以及至少一個易碎連接件固定至所述多個藥用小瓶中的每一個。