The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Isenberg, Jeffrey S.,Roberts, David D.,Maxhimer, Justin
申请号：
AU2009279676
公开号：
AU2009279676B2
申请日:
2009.08.05
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation exposure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment.
