Stephen R. Comeau,Andrew Nixon,Niksa Kastrapeli,Jon A. Kenniston,Gregory P. Conley,Shauna Mason,Allison P. Lindberg,Kristopher Kopacz,Burt Adelman
申请号：
US15541066
公开号：
US20180118851A1
申请日:
2015.12.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are bispecific antibodies that bind to plasma kallikrein (pKal) and Factor XII and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e.g., hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody, comprising: a first polypeptide that comprises a light chain of a first antibody, the light chain comprising a light chain variable region (VL) and a light chain constant region (CL) (e.g., a kappa light chain or a lambda light chain)； and a second polypeptide that comprises a heavy chain of the first antibody, the heavy chain comprising a heavy chain variable region (VH) and a heavy chain constant region (CH).
