Simplified structural mimetics of AIPS as quorum sensing inhibitors

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专利权人:

Wisconsin Alumni Research Foundation

发明人:

Helen Blackwell,Joseph Vasquez,Yiftah Tal Gan

申请号：

US15850300

公开号：

US10597372B2

申请日:

2017.12.21

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria and in particular in Staphylococcus aureus. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful, for example, in treating infections of Staphylococcus bacteria and in particular of Staphylococcus aureus. Methods for treating such bacterial infections are provided.

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