血液脳関門を越える治療分子の輸送の向上

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专利权人:

バイオジェン・エムエイ・インコーポレイテッド

发明人:

ファーリントン, グラハム ケイ.,シスク, ウィリアム

申请号：

JP2014552303

公开号：

JP6247226B2

申请日:

2013.01.10

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., the TMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 VHH. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/