PROBLEM TO BE SOLVED: To provide a biological tissue closing device capable of surely closing an undesirable hole passing through a biological tissue membrane.SOLUTION: The biological tissue closing device includes: a clip provided with an anchor and a deformation part and an arranging device for freely detachably holding the clip, deforming the deformation part, performing the operation of closing a wound hole with the clip, and arranging the clip inside a living body. After the wound hole is closed with the clip by the operation of the arranging device, when a hand part (casing) is moved in a proximal end direction succeedingly, a stopper 121 enters the inside of the hole part 345 of a slide connection member 34 and is engaged with the proximal end part of a fixed tube 7 to block the movement in the proximal end direction of the fixed tube 7, the fitting of the proximal end part of the fixed tube 7 to the slide connection member 34 is released, and the fixed tube 7 is detached from the arranging device.COPYRIGHT: (C)2011,JPO&INPIT【課題】生体内組織膜を貫通する望ましくない穴を確実に閉じることができる生体内組織閉鎖装置を提供すること。【解決手段】生体内組織閉鎖装置は、アンカーおよび変形部を有するクリップと、クリップを着脱自在に保持し、変形部を変形させて傷穴をクリップで閉じる操作を行なって、クリップを生体内に配置する配置装置とを備える。配置装置の作動により、クリップにより傷穴が閉じられた後、引き続き、手元部(ケーシング)を基端方向に移動させると、ストッパー121が、スライド連結部材34の孔部345内に入り、固定チューブ7の基端部に係合し、固定チューブ7の基端方向への移動が阻止され、固定チューブ7の基端部のスライド連結部材34への嵌合が外れ、固定チューブ7は、配置装置から離脱する。【選択図】図19