作為白三烯Ａ４水解酶的調節劑之噻唑并吡啶－２－基氧基－苯基及噻唑并吡－２－基氧基

发明人:: BACANI, GENESIS M.,贝克尼　居尼斯,貝克尼　居尼斯,BROGGINI, DIEGO,柏吉尼　迪亚哥,柏吉尼　迪亞哥,CHEUNG, EUGENE Y.,张仁正,張仁正,CHROVIAN, CHRISTA C.,克罗维　克力思塔,克羅維　克力思塔,DENG, XIAOHU,邓晓虎,鄧曉虎,FOURIE, ANNE M.,芙瑞　安妮,GOMEZ, LAURENT,可麦兹　,贝克尼居尼斯,貝克尼居尼斯,柏吉尼迪亚哥,柏吉尼迪亞哥,克罗维克力思塔,克羅維克力思塔,芙瑞安妮,可麦兹

摘要：: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, Which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.本發明所披露的係噻唑并吡啶-2-基氧基-苯基及噻唑并吡-2-基氧基-苯基胺化合物類，其有用於作為LTA4水解酶(LTA4H)調節物。這樣的化合物可被使用在藥學組成物及用於LTA4H的調節以及用於治療受LTA4水解酶活性介導的疾病狀態、病症及病況之方法中。