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1, 2, 4, 5-Tetrahydro-3H-benzazepine compounds a process for their preparation and pharmaceutical compositions containing them
专利权人:
Les Laboratoires Servier
发明人:
Peglion, Jean-Louis,Goument, Bertrand,Dessinges, Aimee,Caignard, Pascal,Vilaine, Jean-Paul,Thollon, Catherine
申请号:
AU2008207585
公开号:
AU2008207585B2
申请日:
2008.08.28
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
#$%^&*AU2008207585B220130822.pdf#####-89ABSTRACT Compounds of formula (I): R5 R4 R6 (CH 2)n (I) R7 R3 7 (X)m R N R2 R8#D 0 R 9 wherein: 5 - R, represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, - R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxy, methyl, OS0 2 RIO, -OCORio or optionally substituted alkoxy group, or R2 and R3, or R3 and R4, or R4 and R5 together form a group -O-(CH2)q-O-, -0-CH=CH-0- or 10 -O-CH=CH-, - R6, R7, R8 and R9 each represent a hydrogen atom or an alkoxy group, or R6 and R7, or R7 and R8, or R8 and R9 together form a group -O-(CH2)q-O-, - Rio represents a group selected from linear or branched Ci-C 6alkoxy, NR IR',1 and optionally substituted alkyl, 15 - R I and R'1 each represent a hydrogen atom or an alkyl group, or RII and R' 1 together with the nitrogen atom carrying them form an optionally substituted, monocyclic or bicyclic, nitrogen-containing heterocycle, - X represents 0, NH or CH 2, - m and p each represent 0 or 1, 20 - n and q each represent I or 2, in racemic form or in the form of optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid.
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