The object of the present invention relates to the new and surprising use ofsulfated hyaluronic acid (HAS) as regulatoragent of the cytokine activity (pro- and anti-inflammatory) and consequentlythe use of HAS for the preparation of a newmedicine for topic use in the prevention and treatment of pathologiesassociated with the activation and/or deficiency of cytokinesof a pro- and anti-inflammatory nature. The Applicant has in fact discoveredthe exclusive capacity of HAS in modulating the activityof these particular proteins, it has studied the action mechanism anddemonstrated the substantial difference between the differentsulfated types known in the state of the art, but above all it hasdemonstrated an unexpectedly high activity of HAS vs differenttypes and strains of Herpes virus, Cytomegalovirus and the virus of vesicularstomatitis. Finally, a further object of thepresent invention is the use of HAS as a skin absorption promoter of drugs ofan anti-inflammatory nature.
