1. An oral vaccine composition for delivering antigen to the immediate vicinity of the distal ileum of the gastrointestinal tract and possibly to an appendix containing: (a) many nuclei, each of which contains (1) antigen and possibly an adjuvant； (2) first an enteric coating that encapsulates an antigen that is substantially insoluble at a pH below a range of from about 7.0 to about 7.6 and consisting of one or more compositions selected from the group consisting of poly (DL-lactide-glycolide copolymer), chitosan (Chi), stable PVA (polyvinyl alcohol), lipid, alginate, carboxy methyl ethyl cellulose (CMEC), cellulose acetate trimellitate (CAT), hydroxypropyl methyl cellulose phthalate (HPMC), hydroxypropyl methyl cellulose, ethyl cellulose, ethylcellulose and methylcellulose, and methylate PVAP), cellulose acetate phthalate (ATS), shellac, copolymers of methacrylic acid and ethyl acrylate, and copolymers of methacrylic acid and ethyl acrylate, to which methyl acrylate monomer was added during the polymerization ； and optionally (3) a second enteric coating, the composition being the same as the first coating, or different from it, essentially insoluble at a pH below a range of from about 1.0 to about 5.3, which is encapsulated inside the first coating and which consists of one or more compositions selected from the group consisting of polyvinyl acetate phthalate (PVAP), cellulose acetate phthalate (CAP), shellac, copolymers of methacrylic acid and ethyl acrylate, and copolymers of methacrylic acid and ethyl acrylate, to which are added flax methyl acrylate monomer； as well as possible1. Пероральная вакцинная композиция для доставки антигена в область непосредственной близости к дистальному отделу подвздошной кишки желудочно-кишечного тракта и возможно в аппендикс, содержащая:(а) множество ядер, каждое из которых содержит(1) антиген и возможно адъювант；(2) первое энтеросолюбильное покрытие, инкапсулирующее антиген, по существу, нерастворимое при pH ниже диапазона от
