The present invention provides compounds that modulate protein function, to restore protein homeostasis and/or cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions of these compounds are also provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, and conditions are also provided.本發明提供調節蛋白質功能以恢復蛋白質內穩態及/或細胞-細胞黏附之化合物。本發明提供調節蛋白質介導之疾病之方法，該等疾病諸如細胞介素介導之疾病、病症、病狀或反應。亦提供此等化合物之組合物。亦提供治療、改善或預防蛋白質介導之疾病、病症及病狀的方法。
