Compositions and methods of modulating the immune response by activating alpha protein kinase 1

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专利权人:

Shanghai Yao Yuan Biotechnology Co.; Ltd.

发明人:

XU, Tian,XU, Cong,LIU, Danyang,FAN, Jieqing,PAN, Yanfang,LI, Tongruei Raymond,CHEN, Xiaodong

申请号：

AU2018355487

公开号：

AU2018355487A2

申请日:

2018.10.25

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A

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