PROBLEM TO BE SOLVED: To provide a novel tyrosinase inhibitor that is low in skin irritation and skin sensitization, and suitable for external compositions for skin, and a skin-whitening agent.SOLUTION: The present invention provides a tyrosinase inhibitor, a skin-whitening agent, and an external composition for skin comprising the following component (A), or components (A) and (B) as an active ingredient: (A) 3-(2,4-dihydroxyphenyl) propionic acid or salt thereof and (B) ascorbic acid, a derivative thereof, or a salt thereof.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】皮膚刺激性及び皮膚感作性が低く、皮膚外用組成物に適した新規のチロシナーゼ阻害剤、及び美白剤を提供する。【解決手段】下記(A)、または(A)及び(B)を有効成分とするチロシナーゼ阻害剤、美白剤、及び皮膚外用組成物:(A)3-(2,4-ジヒドロキシフェニル)プロピオン酸またはその塩(B)アスコルビン酸、その誘導体、またはこれらの塩。【選択図】なし
