Charles M. Thompson,John M. Gerdes,Syed K. Ahmed,Yamina Belabassi
申请号：
US15258356
公开号：
US20170197996A1
申请日:
2016.09.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides compounds that inhibit cholinesterases, such as acetylcholinesterase and butyrylcholinesterase. Such compounds are useful to prevent or treat exposure of a patient (e.g., a human) to an organophosphoric nerve agent (e.g., sarin and VX) or to treat a patient suffering from a neurodegenerative disorder such as Alzheimers Disease or Lewy Body Dementia. The compounds are further useful as diagnostic tools for use in medical or research radiography (e.g., positron emission tomography) when synthesized with a radionuclide (e.g., [18F]. Synthetic schemes to produce such compounds are also provided.
