Provided herein are compounds, methods and compositions for treating allergic diseases. In particular a short strande short interfering ribonucleic acid (siRNA) which are directed to the genes gata-3, IL-4, IL5, EL- 13 or eotaxin and results in the cleavage of the expressed target RNA via a RNA interference mechanism. Such siRNA is useful as a medicament for treating allergy by alleviating or preventing airway inflammation of a subject.
