Disclosed is a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain which is suitable for production of a derivative having a radioisotope. Specifically disclosed is a method for producing 1-(1- benzoyloxymethyl-2-hydroxyethyl)oxymethyl-2-nitroimidazole, which is characterized in that 1-O-benzoylglycerin is obtained by reacting glycerin with a benzoylating agent, then 4-benzoyloxymethyl-1,3-dioxolane is obtained by reacting 1-O-benzoylglycerin with dimethoxymethane in the presence of a dehydrating agent, and then 4-benzoyloxymethyl-1,3-dioxolane is reacted with 2-nitroimidazole or 2-nitro-1-trialkylsilylimidazole in the presence of a Lewis acid.
