INHIBITEUR PSD-95 POUR LE TRAITEMENT DE L'EPILEPSIE

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专利权人:

ARBOR VITA CORPORATION;NONO INC.

发明人:

GURD, JAMES,DYKSTRA, CRYSTAL,TYMIANSKI, MICHAEL

申请号：

CA2724483

公开号：

CA2724483C

申请日:

2009.05.13

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention provides patients having epilepsy with a treatmentregime whereby administration of an inhibitor of PSD-95, which inhibitsbinding of aPDZ-binding ligand to a PDZ domain of PSD-95, takes place at least one houraftertermination of an episode of epilepsy. The present invention also providesspecific inhibitorsof PSD-95, namely Tat-NR2B9c(SDV) (SEQ ID NO:10), Tat-NR2B9c(TDV) (SEQ IDNO:8)or F-TatNR2B9c(SDV) (SEQ ID NO:46), for treating epilepsy, wherein the aminoacids ofthe inhibitor are natural amino acids.

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