A compound having the structure of Formula (J): ** Formula ** where: n is 0, 1, 2, 3 or 4； m is 0, 1, 2, 3, or 4； q is 0 or 1； W1 is N and W2 is C (Rw)； W3 is CH2 or NH； Rw is hydrogen, halo, or optionally substituted alkyl； A 'is NR5R4, OR4 or NR5C (O) R4； each R1 is independently halo, cyano, optionally substituted alkyl, optionally substituted haloalkyl, substituted alkoxy, hydroxy, optionally substituted sulfonyl, optionally substituted aryl, optionally substituted alkenyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, or optionally substituted heterocycloalkyl； each R2 is independently halo, cyano, optionally substituted alkyl, optionally substituted haloalkyl, optionally substituted alkoxy, or optionally substituted sulfonyl； R3 is hydrogen, optionally substituted alkyl, optionally substituted haloalkyl, optionally substituted cycloalkyl, or optionally substituted aryl； R4 is a monocyclic heteroaryl optionally substituted with one, two, or three members independently selected from halo, cyano, optionally substituted alkyl, -NH2, and alkynyl； R5 is hydrogen or optionally substituted alkyl； or R5 and R3 together with the atoms to which they are attached optionally form an optionally substituted heterocyclic ring； R6 is hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted alkoxy, optionally substituted haloalkyl, optionally substituted sulfonyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl； and R7 is hydrogen, or a pharmaceutically acceptable salt, isomer, or a mixture thereof.Un compuesto que tiene la estructura de Fórmula (J):**Fórmula** en donde: n es 0, 1, 2, 3 o 4； m es 0, 1, 2, 3 o 4； q es 0 o 1； W1 es N y W2 es C(Rw)； W3 es CH2 o NH； Rw es hidrógeno, halo, o alquilo opcionalmente sustituido； A' es NR5R4, OR4 o NR5C(O)R4； cada R1 es independientemente halo, ciano, alquilo opcionalmente sustitu
