Phillip D. Zamore,Gyorgy Hutvagner,Dianne Schwarz,Martin Simard
申请号：
US13654199
公开号：
US09121018B2
申请日:
2012.10.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
