KOENRAAD JOZEF LODEWIJK MARCEL ANDRIES,ANIL KOUL,JÉRÔME EMILE GEORGES GUILLEMONT,ELISABETH THERESE JEANNE PASQUIER
申请号：
MYPI 20055733
公开号：
MY163500A
申请日:
2005.12.07
申请国别(地区):
MY
年份:
2017
代理人:
摘要：
THE PRESENT INVENTION RELATES TO A METHOD FOR THE TREATMENT OF A BACTERIAL INFECTION COMPRISING ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF FORMULA OR A PHARMACEUTICALLY ACCEPTABLE ACID OR BASE ADDITION SALT THEREOF, A STEREOCHEMICALLY ISOMERIC FORM THEREOF OR A N-OXIDE FORM THEREOF, WHEREIN R1 IS HYDROGEN, HALO, POLYHALOC1-6ALKYL, C1-6ALKYL, AR OR HET P IS AN INTEGER EQUAL TO 1 OR 2 R2 IS C1-6ALKYLOXY, C1-6ALKYLOXYC1-6ALKYLOXY OR C1-6ALKYLTHIO R3 IS AR, HET OR HET1 R4 AND R5 EACH INDEPENDENTLY ARE HYDROGEN, C1-6ALKYL OR BENZYL OR R4 AND R5 TOGETHER AND INCLUDING THE N TO WHICH THEY ARE ATTACHED MAY FORM A RADICAL SELECTED FROM THE GROUP OF PYRROLIDINYL, 2-PYRROLINYL, 3-PYRROLINYL, PYRROLYL, IMIDAZOLIDINYL, PYRAZOLIDINYL, 2- IMIDAZOLINYL, 2-PYRAZOLINYL, IMIDAZOLYL, PYRAZOLYL, TRIAZOLYL, PIPERIDINYL, PYRIDINYL, PIPERAZINYL, PYRIDAZINYL, PYRIMIDINYL, PYRAZINYL, TRIAZINYL, MORPHOLINYL AND THIOMORPHOLINYL, EACH OF SAID RINGS MAY OPTIONALLY BE SUBSTITUTED WITH C1-6ALKYL, HALO, POLYHALOC1-6ALKYL, HYDROXY, HYDROXYC1-6ALKYL, C1-6ALKYLOXY, AMINO, MONO- OR DI(C1-6ALKYL)AMINO, C1-6ALKYLTHIO, C1-6ALKYLOXYC1-6ALKYL, C1-6ALKYLTHIOC1-6ALKYL OR PYRIMIDINYL R6 IS HYDROGEN, HALO, POLYHALOC1-6ALKYL, C1-6ALKYL, C1-6ALKYLOXY, C1-6ALKYLTHIO OR TWO VICINAL R6 RADICALS MAY BE TAKEN TOGETHER TO FORM A BIVALENT RADICAL OF FORMULA —CH=CH—CH=CH— R IS AN INTEGER EQUAL TO 1 OR 2 R7 IS HYDROGEN, C1-6ALKYL, AR, HET OR HET1 PROVIDED THAT TO BACTERIAL INFECTION IS OTHER THAN A MYCOBACTERIAL INFECTION.
