The present disclosure provides pharmaceutical formulations for sustained release, and methods for delivering a treatment regimen with a combination of sustained release and long half-life formulations. The disclosure provides improved pharmacokinetics for peptide and small molecule drugs. In some aspects, the disclosure provides a sustained release pharmaceutical formulation. The formulation includes a therapeutic agent for systemic administration, where the therapeutic agent includes an active agent and an amino acid sequence capable of forming a reversible matrix at the body temperature of a subject.La présente invention concerne des compositions pharmaceutiques pour libération prolongée et des procédés d'administration d'un schéma de traitement combinant compositions à libération prolongée et compositions à demi-vie longue. La présente invention concerne également l'amélioration de la pharmacocinétique de médicaments à base de peptides et de petites molécules.
