PROBLEM TO BE SOLVED: To provide an antibody drug useful for the treatment of multiple myeloma. SOLUTION: An isolated human monoclonal antibody that binds to a CD38 antigen expressed in a large amount on the surface of human blood cells, particularly malignant plasma cells such as multiple myeloma, and compositions and molecules based on related antibodies. Also, pharmaceutical compositions containing human antibodies, as well as therapeutic and diagnostic methods for using human antibodies. [Selection diagram] None【課題】多発性骨髄腫の治療に有用な抗体医薬を提供する。【解決手段】ヒト血液細胞、特に多発性骨髄腫等の悪性形質細胞表面に多量に発現するCD38抗原に結合する、単離されたヒトモノクローナル抗体、ならびに関連抗体に基づく組成物および分子。また、ヒト抗体を含む薬学的組成物、ならびにヒト抗体を用いるための治療法および診断法。【選択図】なし
