KAPLAN, DAVID L.,TSIORIS, KONSTANTINOS,OMENETTO, FIORENZO G.,PRITCHARD, ELEANOR M.
申请号：
CA2815285
公开号：
CA2815285C
申请日:
2011.10.19
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A microneedle or microneedle device includes a microneedle body extending froma base to a penetrating tip formedfrom a silk fibroin based material, which is easy to fabricate and highlybiocompatible. The microneedle device can include one ormore microneedles mounted to a substrate. The silk fibroin can include activeagents to be transported into or across biologicalbarriers such as skin, tissue and cell membranes. The silk fibroinmicroneedles can be fully or partially biodegradable and/or bioerodible.The silk fibroin is highly stable, affords room temperature storage and isimplantable. The silk fibroin structure can be modulated tocontrol the rate of active agent delivery.
