The present invention is directed to stable liquid growth hormone formulationsthat remain stable after physical agitation, and after exposure to one or morefreeze-thaw events. Formulations of the present invention can be stored longterm at a variety of temperatures, even frozen. In the present invention, acombination of buffer and stabilizing agents, including a non-ionic surfactant(e.g., polysorbate 20), a polymer stabilizer (e.g., polyethylene glycol), andother optional stabilizers combine to provide unexpected stability to aqueousformulations of a growth hormone (e.g., human growth hormone).
