Dunne, Aisling,O'Neill, Luke Anthony John,ONeill, Luke Anthony John
申请号：
AU2006238475
公开号：
AU2006238475B2
申请日:
2006.04.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
An isolated polypeptide comprises an amino acid sequence of SEQ ID No. 1 or 2 or a variant or fragment thereof. The variant may comprise an amino acid sequence that is at least 70% or 95% identical to the amino acid sequence of SEQ ID No. 1 or 2. A fragment thereof may be a peptide comprising at least 12 contiguous amino acids of SEQ ID No. 1 or 2. The polypeptide exhibits toll-like receptor activity. The TLR has been named TLRl 4. TLR receptors recognise a range of ligands and activate a series of signalling pathways that lead to the induction of immune and inflammatory genes.
